Ratio of high-fat diet intake of pups nursed by dams fed combination diet was lower than that of pups nursed by dams fed high-fat or low-fat diet.

To investigate the influence of fat-feeding dams on the food choice of their pups after weaning, each of three groups of dams was fed a low-fat diet (LHD), a high-fat diet (HFD) or a two-choice diet of LFD and HFD during pregnancy and lactation. Immediately after weaning, all pups were placed on a two-choice diet program for 5 wk. The fat energy ratio (F ratio) for dams fed the two-choice diet was 31%. Although no significant differences in body weight or calorie intake were observed between these three groups of dams, liver and perirenal fat tissue weights and plasma and liver trigluceride and total-cholesterol concentrations were lower in dams fed the two-choice diet than in dams fed LHD or HFD. Both groups of pups nursed by dams fed LFD or HFD continued to eat a large amount of HFD after weaning (F ratio was over 40%). Although within first week after weaning, no significant difference in the ratio of HFD intake was observed among the three groups of pups, the ratio for pups nursed by dams fed the two-choice diet decreased after the second week. The F ratio for pups nursed by dams fed the two-choice diet was 32%. These data lead us to conclude that if dams ate more than one diet in an adequate PFC ratio, their pups would have the ability to eat adequately after weaning.